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c┐myc基因蛋白在外陰白斑和外陰鱗癌中的表達及臨床意義
作者：樊 昕 ，余春艷，趙一嶺
關(guān)鍵詞: 原癌基因蛋白質(zhì)c-myc類;外陰白斑;外陰腫瘤;免疫組織化學(xué)
摘 要:目的 研究c-myc基因蛋白在外陰白斑和外陰鱗癌中的表達. 方法 采用SABC免疫組化法，對71例外陰白斑和21例外陰鱗癌標本進行c-myc基因蛋白檢測. 結(jié)果 c-myc基因蛋白在正常組織中主要分布在細胞核，外陰白斑各型和鱗癌組織中主要分布在細胞漿.外陰白斑各型與鱗癌組相比較，經(jīng)χ2 檢驗，正常組(χ2 =11.072，P<0.05)、增生組(χ2 =5.692，P<0.05)、硬化萎縮組(χ2 =16.488，P<0.05)、混合組(χ2 =6.497，P<0.05)和不典型增生組(χ2 =1.072，P>0.05).21例鱗癌標本，Ⅰ級，Ⅱ級，Ⅲ級中c-myc蛋白的陽性率分別為100.0%(9/9)，85.7%(6/7)，60.0%(3/5). 結(jié)論 c-myc基因蛋白的表達和分布與外陰白斑分型有關(guān)，外陰鱗癌和不典型增生組織中表達陽性率明顯高于外陰白斑各型，c-myc基因蛋白的過度表達可能與外陰鱗癌的發(fā)生有一定的關(guān)系.
Clinical significance and expression of c┐myc gene protein in genitalia leukoplakia and squamous cell carcinoma of vulva
FAN Xin，YU Chun-Yan，ZHAO Yi-Ling
Department of Dermatology，Tangdu Hospital，Xi`an710038，Department of Pathology，F(xiàn)aculty of Preclinical Medicine，F(xiàn)ourth Military Medical U-niversity，Xi'an710033，China
Keywords:proto-oncogene proteins c-myc;leukoplakia vul-vae;vulvar neoplasms;immunohistochemistry
Abstract:AIM To study the expression of c-myc gene pro-tein in genitalia leukoplakia and squamous cell carcinoma of vulva.METHODS The genitalia leukoplakia in71cases and squamous cell carcinoma in21cases were detected with c-myc gene protein by SABC immunohistochemical technique.RESULTS c-myc gene protein was mainly distributed in the cell nucleus in normal tissue and in the cell cytoplasm in hy-perplasia type，atypical hyperplasia and squamous cell carci-noma.χ2 test showed significant difference between the squa-mous cell carcinoma and the other types of benign pathologi-cal changes except the type of atypical hyperplasia(χ2 =1.072，P>0.05):Normal group(χ2 =11.027，P<0.05);hyperplasia type group(χ2 =5.692，P<0.05);sclerotic at-rophic type group(χ2 =16.488，P<0.05);mixed type group(χ2 =6.497，P<0.05).The positive rates of c-myc gene pro-tein in the different stages of squamous cell carcinoma group(21cases)were100.0%(9/9)in stage I，85.7%(6/7)in stageⅡ，and60.0%(3/5)in stageⅢrepectively.CONCLUSION Expression and distribution of c-myc gene protein might be correlated with the types of genitalia leuko-plakia.c-myc gene protein has a higher expression rate in squamous cell carcinoma of vulva and atypical hyperplasia than that in various types of genitalia leukoplakia.These data suggest that overexpression of c-myc gene protein may be re-lated to the oncogenesis of squamous cell carcinoma of vulva.
