【參考文獻】
[1] Griffin JD.Central thermosensitivity and the integrative responses of hypothalamic neurons[J].J Therm Biol,2004,29:327331.
[2] Griffin JD,Saper CB,Boulant JA.Synaptic and morphological characteristics of temperaturesensitive and insensitive rat hypothalamic neurones[J].J Physiol,2001,537:521535.
[3] Wagner EJ,ReyesVazquez C,Ronnekleiv OK,et al.The role of intrinsic and agonistactivated conductances in determining the firing patterns of preoptic area neurons in the guinea pig[J].Brain Res,2000,879(12):2941.
[4] Robinson RB,Siegelbaum SA.Hyperpolarizationactivated cation currents:from molecules to physiological function[J].Annu Rev Physiol,2003,65:453480.
[5] Monteggia LM,Eisch AJ,Tang MD,et al.Cloning and localization of the hyperpolarizationactivated cyclic nucleotidegated channel family in rat brain[J].Brain Res Mol Brain Res,2000,81(12):129139.
[6] Santoro B,Chen S,Luthi A,et al.Molecular and functional heterogeneity of hyperpolarizationactivated pacemaker channels in the mouse CNS[J].J Neurosci,2000,20(14):52645275醫(yī).學.全.在.線m.bhskgw.cn.
[7] Han J,Gnatenco C,Sladek CD,et al.Background and tandempore potassium channels in magnocellular neurosecretory cells of the rat supraoptic nucleus[J].J Physiol,2003,546:625639.
[8] Kang D,Choe C,Kim D.Thermosensitivity of the twopore domain K+ channels TREK2 and TRAAK[J].J Physiol,2005,564:103116.
[9] Patel AJ,Honore E.Properties and modulation of mammalian 2P domain K+ channels[J].Trends Neurosci,2001,24(6):339346.
[10] Wechselberger M,Wright CL,Bishop GA,et al.Ionic channels and conductancebased models for hypothalamic neuronal thermosensitivity[J].Am J Physiol Regul Integr Comp Physiol,2006,291(3):R518529.
[11] Unger NT,Kaple ML,Bishop GA,et al.Role of hyperpolarizationactivated currents in hypothalamic neuronal thermosensitivity[J].The FASEB Journal,2007,21:923929.
[12] Wright CL,Burgoon PW,Bishop GA,et al.Cyclic GMP alters the firing rate and thermosensitivity of hypothalamic neurons[J].Am J Physiol Regul Integr Comp Physiol,2008,294(5):17041715.
[13] Zhao Y,Boulant JA.Temperature effects on neuronal membrane potentials and inward currents in rat hypothalamic tissue slices[J].J Physiol,2005,564:245257.
[14] Ranels HJ,Griffin JD.Effects of prostaglandin E2 on the electrical properties of thermally classified neurons in the ventromedial preoptic area of the rat hypothalamus[J].BMC Neurosci,2005,6:14.
[15] Guler AD,Lee H,Iida T,et al.Heatevoked activation of the ion channel,TRPV4[J].J Neurosci,2002,22(15):64086414.
[16] Benham CD,Gunthorpe MJ,Davis JB.TRPV channels as temperature sensors[J].Cell Calcium,2003,33(56):479487.
[17] Kobayashi S,Hori A,Matsumura K,et al.Point:Heatinduced membrane depolarization of hypothalamic neurons:a putative mechanism of central thermosensitivity[J].Am J Physiol Regul Integr Comp Physiol,2006,290(5):14791480.
[18] Unger NT,Kaple ML,Boulant JA.TRPV blockade by ruthenium red does not suppress thermosensitivity in hypothalamic neurons[J].The FASEB Journal,2008,22:956.15.
[19] SharifNaeini R,Ciura S,Bourque CW.TRPV1 gene required for thermosensory transduction and anticipatory secretion from vasopressin neurons during hyperthermia[J].Neuron,2008,58(2):179185.
[20] Tabarean IV,Conti B,Behrens M,et al.Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture[J].Neuroscience,2005,135(2):433449.
[21] Boulant JA.Counterpoint:Heatinduced membrane depolarization of hypothalamic neurons:an unlikely mechanism of central thermosensitivity[J].Am J Physiol Regul Integr Comp Physiol,2006,290(5):14811484.
[22] Reid G,Flonta M.Cold transduction by inhibition of a background potassium conductance in rat primary sensory neurones[J].Neurosci Lett,2001,297(3):171174.
[23] McKemy DD,Neuhausser WM,Julius D.Identification of a cold receptor reveals a general role for TRP channels in thermosensation[J].Nature,2002,416(6876):5258.
[24] Simon E.Ion channel proteins in neuronal temperature transduction:from inferences to testable theories of deepbody thermosensitivity[J].Am J Physiol Regul Integr Comp Physiol,2006,291(3):515517.