醫(yī)學(xué)全在線
醫(yī)學(xué)全在線首頁-醫(yī)師-藥師-護(hù)士-衛(wèi)生資格-高級職稱-考試題庫-網(wǎng)校-考研-圖譜-下載-招聘  
分類
國家級省級浙江省各省雜志
科技核心北大核心CSCDCSCD擴(kuò)展
工具
期刊知識寫作指導(dǎo) 論文投稿推薦期刊
期刊驗(yàn)證論文檢測 錄用通知往期目錄
SCI
SCI指導(dǎo)影響因子
期刊點(diǎn)評基金動(dòng)態(tài)
其它
經(jīng)濟(jì)教育計(jì)算機(jī)
建筑體育農(nóng)業(yè)
北京|天津|河北|山西|湖北|江蘇|安徽|山東|上海|浙江|江西|福建|湖南|寧夏|內(nèi)蒙古|河南
四川|重慶|貴州|云南|遼寧|吉林|廣東|廣西|海南|陜西|甘肅|新疆|青海|衛(wèi)生部直屬|黑龍江|兵團(tuán)
您現(xiàn)在的位置: 醫(yī)學(xué)全在線 > 醫(yī)學(xué)論文 > 論文投稿 > 正文:醫(yī)學(xué)免費(fèi)論文:黃芪對高脂血癥小鼠血脂及脂質(zhì)過氧化的影響
    

醫(yī)學(xué)免費(fèi)論文:黃芪對高脂血癥小鼠血脂及脂質(zhì)過氧化的影響

來源:本站原創(chuàng) 更新:2013-10-15 論文投稿平臺(tái)

醫(yī)學(xué)免費(fèi)論文:黃芪高脂血癥小鼠血脂及脂質(zhì)過氧化的影響

【關(guān)鍵詞】 高脂血癥;過氧化脂質(zhì);植物,藥用

[摘要] [目的] 探討黃芪對高脂血癥小鼠血脂及脂質(zhì)過氧化的影響. [方法] 取小鼠隨機(jī)分組,除正常組外的其他組小鼠灌胃給予脂肪乳劑,建立高脂血癥小鼠模型,分別灌胃給予不同劑量黃芪組小鼠18.0,9.0,4.5g/kg黃芪水提取物,連續(xù)4周,測定各組小鼠血清總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDL-C)及低密度脂蛋白膽固醇(LDL-C)含量,谷胱甘肽過氧化物酶(GSH-Px)和超氧化化物歧化酶(SOD)活性,脂質(zhì)過氧化物(LPO)含量. [結(jié)果] 不同劑量黃芪組小鼠血清TC,TG,LDL-C含量明顯下降,SOD,GSH-Px活性明顯增強(qiáng),血清LPO含量明顯下降. [結(jié)論] 黃芪具有調(diào)節(jié)小鼠血脂代謝及增強(qiáng)機(jī)體抗脂質(zhì)過氧化的作用.

[關(guān)鍵詞] 高脂血癥;過氧化脂質(zhì);植物,藥用

Effects of Astragalus on serum lipids and lipoperoxidation in experimental hyper lipidemic mice

JIN Guang-xian 1 ,ZHANG Xue-wu 2^

(Department of Pathology and Forensic Medicine;Department of Biochemistry and Molecular Biology:Yanbian University College of Basic Medicine,Yanji133000,Jilin,China)

ABSTRACT:OBJECTIVE To investigate the effects of Astragalus on serum lipids and lipoperoxidation in experimental hyperlipidemic mice.METHODS The mice were randomly divided,and apart from the mice in normal group,all the mice in other groups were fed with lipid emulsion for4weeks.After the in experimental hyper lipidemic mice were succeed,different dosages of experimental control groups in which the mice were treated with Astragalus at dosages of18.0,9.0,4.5g/kg respectively.After4weeks,the TC,TG,HDL-c,LDL-c,SOD,GSH-Px and LPO in serum were measured.RESULTS Astragalus could significantly decrease the serum TC,TG,HDL-c in the experimental hyperlipidemic mice,and markedly increase the level of serum HDL-c.Mean level of serum LPO in the experimental groups treated by Astragalus at different dosages were much lower than that in hyper lipidema group,and the SOD and GSH-Px activities of serum in the group of Astragalus were much higher than those in hyper lipidema group.CONCLUSIONAstragalus can regulate lipid metabolism,enhance the antioxidation and reduce the lipid peroxidation in mice with hyperlipidemia醫(yī).學(xué).全.在.線m.bhskgw.cn.

Key words:hyperglycemia;lipid peroxides;plants,medicinal

黃芪具有補(bǔ)氣升陽、固表止汗、脫瘡生肌及利水消腫之功效,用于治療表虛自汗、陽虛血脫及水腫血痹等癥.本研究探討了黃芪水提取物對高脂血癥小鼠體內(nèi)血脂及脂質(zhì)過氧化的影響.

1 材料與方法

1.1 材料

1.1.1 實(shí)驗(yàn)動(dòng)物 取昆明種小鼠,雌雄各半,體重為18~22g,由延邊大學(xué)醫(yī)學(xué)部實(shí)驗(yàn)動(dòng)物科提供. 1.1.2 藥物與試劑 丙基硫氧嘧啶為上海復(fù)興朝輝藥業(yè)有限公司產(chǎn)品;膽固醇為去氧膽酸鈉;豬油為自制;實(shí)驗(yàn)所需其他試劑均為國產(chǎn)分析純.GSH-Px,SOD,LPO試劑盒均為南京建成生物工程研究所產(chǎn)品.722型分光光度計(jì)為中國廈門分析儀器廠產(chǎn)品;7600-010型全自動(dòng)生物化學(xué)檢測儀為日本日立公司產(chǎn)品;低溫高速離心機(jī)為美國Sigma公司產(chǎn)品. 1.2 方法


[1] [2] [3] 下一頁

...
關(guān)于我們 - 聯(lián)系我們 -版權(quán)申明 -誠聘英才 - 網(wǎng)站地圖 - 網(wǎng)絡(luò)課程 - 幫助
醫(yī)學(xué)全在線 版權(quán)所有© CopyRight 2006-2046, MED126.COM, All Rights Reserved
浙ICP備12017320號
百度大聯(lián)盟認(rèn)證綠色會(huì)員實(shí)名網(wǎng)站 360認(rèn)證可信網(wǎng)站 中網(wǎng)驗(yàn)證